Association between Thiopurine S-methyltransferase Polymorphisms and Thiopurine-Induced Adverse Drug Reactions in Patients with Inflammatory Bowel Disease: A Meta-Analysis

PURPOSE: Thiopurine drugs are well established treatments in the management of inflammatory bowel disease (IBD), but their use is limited by significant adverse drug reactions (ADRs). Thiopurine S-methyltransferase (TPMT) is an important enzyme involved in thiopurine metabolism. Several clinical gui...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Liu, Yue-Ping, Wu, Hai-Yan, Yang, Xiang, Xu, Han-Qing, Li, Yong-Chuan, Shi, Da-Chuan, Huang, Jun-Fu, Huang, Qing, Fu, Wei-Ling
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370632/
https://ncbi.nlm.nih.gov/pubmed/25799415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121745
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