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Codon Optimization of the Human Papillomavirus E7 Oncogene Induces a CD8(+) T Cell Response to a Cryptic Epitope Not Harbored by Wild-Type E7
Codon optimization of nucleotide sequences is a widely used method to achieve high levels of transgene expression for basic and clinical research. Until now, immunological side effects have not been described. To trigger T cell responses against human papillomavirus, we incubated T cells with dendri...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4370481/ https://ncbi.nlm.nih.gov/pubmed/25799237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121633 |
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