Dysregulated Serum IL-23 and SIRT1 Activity in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis

Sirtuin 1 (Sirt1) is a class III histone deacetylase (HDAC) that modulates gene expression and is involved in the regulation of proinflammatory cytokines. Interleukin-23 (IL-23) is produced by activated macrophages and dendritic cells and could fuel the progression of rheumatoid arthritis (RA). The...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wendling, Daniel, Abbas, Wasim, Godfrin-Valnet, Marie, Kumar, Amit, Guillot, Xavier, Khan, Kashif Aziz, Vidon, Claire, Coquard, Laurie, Toussirot, Eric, Prati, Clément, Herbein, Georges
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370395/
https://ncbi.nlm.nih.gov/pubmed/25799392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119981
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