Imbalance between HAT and HDAC Activities in the PBMCs of Patients with Ankylosing Spondylitis or Rheumatoid Arthritis and Influence of HDAC Inhibitors on TNF Alpha Production

OBJECTIVE: Acetylation or deacetylation of histone proteins may modulate cytokine gene transcription such as TNF alpha (TNF). We evaluated the balance between histone deacetytlase (HDAC) and histone acetyltransferase (HAT) in patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) com...

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Détails bibliographiques
Auteurs principaux: Toussirot, Eric, Abbas, Wasim, Khan, Kashif Aziz, Tissot, Marion, Jeudy, Alicia, Baud, Lucile, Bertolini, Ewa, Wendling, Daniel, Herbein, Georges
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
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Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748901/
https://ncbi.nlm.nih.gov/pubmed/24039666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070939
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