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Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking
Exposure to hydrogen peroxide (H(2)O(2)), one of the reactive oxidants in the gas phase of cigarette smoke (CS), induces aberrant phosphorylation of the epidermal growth factor receptor (EGFR), resulting in the lack of ubiquitination by c-Cbl, and impaired degradation. EGFR activation without the fe...
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| Veröffentlicht in: | FASEB J |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4370285/ https://ncbi.nlm.nih.gov/pubmed/17971399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.06-7729com |
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