Discovery of Specific Inhibitors for Intestinal E. coli   β-Glucuronidase through In Silico Virtual Screening

Glucuronidation is a major metabolism process of detoxification for carcinogens, 4-(methylnitrosamino)-1-(3-pyridy)-1-butanone (NNK) and 1,2-dimethylhydrazine (DMH), of reactive oxygen species (ROS). However, intestinal E. coli    β-glucuronidase (eβG) has been considered pivotal to colorectal carci...

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Veröffentlicht in:ScientificWorldJournal
Hauptverfasser: Cheng, Ta-Chun, Chuang, Kuo-Hsiang, Roffler, Steve R., Cheng, Kai-Wen, Leu, Yu-Lin, Chuang, Chih-Hung, Huang, Chien-Chaio, Kao, Chien-Han, Hsieh, Yuan-Chin, Chang, Long-Sen, Cheng, Tian-Lu, Chen, Chien-Shu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370192/
https://ncbi.nlm.nih.gov/pubmed/25839056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/740815
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