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CCR5 Knockout Prevents Neuronal Injury and Behavioral Impairment Induced in a Transgenic Mouse Model by a CXCR4-using HIV-1 Glycoprotein 120()

The innate immune system has been implicated in several neurodegenerative diseases, including human immunodeficiency virus (HIV)-1 associated dementia. Here we show that genetic ablation of CCR5 prevents microglial activation and neuronal damage in a transgenic model of HIV-associated brain injury i...

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Bibliografske podrobnosti
izdano v:J Immunol
Main Authors: Maung, Ricky, Hoefer, Melanie M., Sanchez, Ana B., Sejbuk, Natalia E., Medders, Kathryn E., Desai, Maya K., Catalan, Irene C., Dowling, Cari C., de Rozieres, Cyrus M., Garden, Gwenn A., Russo, Rossella, Roberts, Amanda J., Williams, Roy, Kaul, Marcus
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370188/
https://ncbi.nlm.nih.gov/pubmed/25031461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302915
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