CCR5 Knockout Prevents Neuronal Injury and Behavioral Impairment Induced in a Transgenic Mouse Model by a CXCR4-using HIV-1 Glycoprotein 120()

The innate immune system has been implicated in several neurodegenerative diseases, including human immunodeficiency virus (HIV)-1 associated dementia. Here we show that genetic ablation of CCR5 prevents microglial activation and neuronal damage in a transgenic model of HIV-associated brain injury i...

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Bibliographic Details
Published in:J Immunol
Main Authors: Maung, Ricky, Hoefer, Melanie M., Sanchez, Ana B., Sejbuk, Natalia E., Medders, Kathryn E., Desai, Maya K., Catalan, Irene C., Dowling, Cari C., de Rozieres, Cyrus M., Garden, Gwenn A., Russo, Rossella, Roberts, Amanda J., Williams, Roy, Kaul, Marcus
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370188/
https://ncbi.nlm.nih.gov/pubmed/25031461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302915
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