NOVEL NON-CALCEMIC SECOSTEROIDS THAT ARE PRODUCED BY HUMAN EPIDERMAL KERATINOCYTES PROTECT AGAINST SOLAR RADIATION

CYP11A1 hydroxylates the side chain of vitamin D3 (D3) in a sequential fashion [D3→20S(OH)D3→20,23(OH)(2)D3→ 17,20,23(OH)(3)D3], in an alternative to the classical pathway of activation [D3→25(OH)D3→1,25(OH)(2)D3]. The products/intermediates of the pathway can be further modified by the action of CY...

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Detalhes bibliográficos
Publicado no:J Steroid Biochem Mol Biol
Main Authors: Slominski, Andrzej T., Janjetovic, Zorica, Kim, Tae-Kang, Wasilewski, Piotr, Rosas, Sofia, Hanna, Sherie, Sayre, Robert M., Dowdy, John C., Li, Wei, Tuckey, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369786/
https://ncbi.nlm.nih.gov/pubmed/25617667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2015.01.014
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