Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat.

Nitrous oxide, by inactivating cobalamin in vivo, produces a suitable animal model for cobalamin 'deficiency.' The synthesis of folate polyglutamate with tetrahydrofolate as substrate is severely impaired in the N2O-treated rat, but is normal with formyltetrahydrofolate as substrate. Methionine rest...

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Pubblicato in:	J Clin Invest
Autori principali:	Perry, J, Chanarin, I, Deacon, R, Lumb, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1983
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC436978/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6853707/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110867
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