Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat.
Nitrous oxide, by inactivating cobalamin in vivo, produces a suitable animal model for cobalamin 'deficiency.' The synthesis of folate polyglutamate with tetrahydrofolate as substrate is severely impaired in the N2O-treated rat, but is normal with formyltetrahydrofolate as substrate. Methionine rest...
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| 發表在: | J Clin Invest |
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| Principais autores: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Clinical Investigation
1983
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC436978/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6853707/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110867 |
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