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Regulation of p53 by Mdm2 E3 Ligase Function is Dispensable in Embryogenesis and Development but Essential in Response to DNA Damage
Mdm2 E3 ubiquitin ligase-mediated p53 degradation is generally accepted as the major mechanism for p53 regulation; nevertheless, the in vivo significance of this function has not been unequivocally established. Here, we have generated an Mdm2(Y487A) knock-in mouse; Mdm2(Y487A) mutation inactivates M...
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| Publicat a: | Cancer Cell |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4369778/ https://ncbi.nlm.nih.gov/pubmed/25117711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.06.006 |
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