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Pharmacophore elucidation and molecular docking studies on phosphodiesterase-5 inhibitors

cGMP-binding cGMP-specific PDE, PDE5 plays a key role in the hydrolysis of cyclic guanidine monophosphate. Because cGMP mediates vascular functions, a PDE5 inhibitor that elevates cGMP level is an attractive means for vasodilatation and treatment of erectile dysfunction. In this paper we report the...

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Bibliografiske detaljer
Udgivet i:Bioinformation
Hovedforfatter: Radwan, Awwad Abdoh
Format: Artigo
Sprog:Inglês
Udgivet: Biomedical Informatics 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369680/
https://ncbi.nlm.nih.gov/pubmed/25848165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6026/97320630011063
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