The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing

DNA methylation is a conserved epigenetic mark that plays important roles in plant and vertebrate development, genome stability, and gene regulation. Canonical Methyl-CpG-Binding Domain (MBD) proteins are important interpreters of DNA methylation that recognize methylated CG sites and recruit chroma...

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Publié dans:Mol Cell
Auteurs principaux: Lang, Zhaobo, Lei, Mingguang, Wang, Xingang, Tang, Kai, Miki, Daisuke, Zhang, Huiming, Mangrauthia, Satendra K., Liu, Wenshan, Nie, Wenfeng, Ma, Guojie, Yan, Jun, Duan, Cheng-Guo, Hsu, Chuan-Chih, Wang, Chunlei, Tao, W. Andy, Gong, Zhizhong, Zhu, Jian-Kang
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369450/
https://ncbi.nlm.nih.gov/pubmed/25684209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.009
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