Rare loss-of-function mutation in complement component C3 provides insight into molecular and pathophysiological determinants of complement activity

The plasma protein C3 is a central element in the activation and effector functions of the complement system. A hereditary dysfunction of C3 that prevents complement activation via the alternative pathway (AP) was described previously in a Swedish family, but its genetic cause and molecular conseque...

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Veröffentlicht in:J Immunol
Hauptverfasser: Sfyroera, Georgia, Ricklin, Daniel, Reis, Edimara S., Chen, Hui, Wu, Emilia L., Kaznessis, Yiannis N., Ekdahl, Kristina N., Nilsson, Bo, Lambris, John D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369434/
https://ncbi.nlm.nih.gov/pubmed/25712219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402781
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