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Rare loss-of-function mutation in complement component C3 provides insight into molecular and pathophysiological determinants of complement activity
The plasma protein C3 is a central element in the activation and effector functions of the complement system. A hereditary dysfunction of C3 that prevents complement activation via the alternative pathway (AP) was described previously in a Swedish family, but its genetic cause and molecular conseque...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4369434/ https://ncbi.nlm.nih.gov/pubmed/25712219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402781 |
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