Validation of a Rapid and Sensitive LC-MS/MS Method for Determination of Exemestane and Its Metabolites, 17β-Hydroxyexemestane and 17β-Hydroxyexemestane-17-O-β-D-Glucuronide: Application to Human Pharmacokinetics Study

A novel, rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the evaluation of exemestane pharmacokinetics and its metabolites, 17β-dihydroexemestane (active metabolite) and 17β-dihydroexemestane-17-O-β-D-glucuronide (inactive metabol...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Wang, Ling-Zhi, Goh, Sok-Hwei, Wong, Andrea Li-Ann, Thuya, Win-Lwin, Lau, Jie-Ying Amelia, Wan, Seow-Ching, Lee, Soo-Chin, Ho, Paul C., Goh, Boon-Cher
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368747/
https://ncbi.nlm.nih.gov/pubmed/25793887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118553
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki