Protein Dynamics Associated with Failed and Rescued Learning in the Ts65Dn Mouse Model of Down Syndrome

Down syndrome (DS) is caused by an extra copy of human chromosome 21 (Hsa21). Although it is the most common genetic cause of intellectual disability (ID), there are, as yet, no effective pharmacotherapies. The Ts65Dn mouse model of DS is trisomic for orthologs of ∼55% of Hsa21 classical protein cod...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ahmed, Md. Mahiuddin, Dhanasekaran, A. Ranjitha, Block, Aaron, Tong, Suhong, Costa, Alberto C. S., Stasko, Melissa, Gardiner, Katheleen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368539/
https://ncbi.nlm.nih.gov/pubmed/25793384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119491
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