Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3(+) Treg cell function in the intestine

Elevated levels of interleukin-18 (IL-18) are found in many chronic inflammatory disorders, including inflammatory bowel disease (IBD), and polymorphisms in the IL18R1-IL18RAP locus are associated with IBD susceptibility. IL-18 is an IL-1 family cytokine that has been proposed to promote barrier fun...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mucosal Immunol
Main Authors: Harrison, OJ, Srinivasan, N, Pott, J, Schiering, C, Krausgruber, T, Ilott, NE, Maloy, KJ
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368110/
https://ncbi.nlm.nih.gov/pubmed/25736457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2015.13
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