Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells

BACKGROUND: Cell proliferation is a hallmark of cancer and depends on complex signaling networks that are chiefly supported by protein kinase activities. Therapeutic strategies have been used to target specific kinases but new methods are required to identify combined targets and improve treatment....

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Vydáno v:BMC Genomics
Hlavní autoři: Nizard, Philippe, Ezan, Frédéric, Bonnier, Dominique, Le Meur, Nolwenn, Langouët, Sophie, Baffet, Georges, Arlot-Bonnemains, Yannick, Théret, Nathalie
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367906/
https://ncbi.nlm.nih.gov/pubmed/25540073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-1169
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