Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells

BACKGROUND: Cell proliferation is a hallmark of cancer and depends on complex signaling networks that are chiefly supported by protein kinase activities. Therapeutic strategies have been used to target specific kinases but new methods are required to identify combined targets and improve treatment....

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Publicado en:BMC Genomics
Autores principales: Nizard, Philippe, Ezan, Frédéric, Bonnier, Dominique, Le Meur, Nolwenn, Langouët, Sophie, Baffet, Georges, Arlot-Bonnemains, Yannick, Théret, Nathalie
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367906/
https://ncbi.nlm.nih.gov/pubmed/25540073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-1169
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