Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells

BACKGROUND: Cell proliferation is a hallmark of cancer and depends on complex signaling networks that are chiefly supported by protein kinase activities. Therapeutic strategies have been used to target specific kinases but new methods are required to identify combined targets and improve treatment....

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Detalhes bibliográficos
Publicado no:BMC Genomics
Main Authors: Nizard, Philippe, Ezan, Frédéric, Bonnier, Dominique, Le Meur, Nolwenn, Langouët, Sophie, Baffet, Georges, Arlot-Bonnemains, Yannick, Théret, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367906/
https://ncbi.nlm.nih.gov/pubmed/25540073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-1169
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