Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells

BACKGROUND: Cell proliferation is a hallmark of cancer and depends on complex signaling networks that are chiefly supported by protein kinase activities. Therapeutic strategies have been used to target specific kinases but new methods are required to identify combined targets and improve treatment....

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Dades bibliogràfiques
Publicat a:BMC Genomics
Autors principals: Nizard, Philippe, Ezan, Frédéric, Bonnier, Dominique, Le Meur, Nolwenn, Langouët, Sophie, Baffet, Georges, Arlot-Bonnemains, Yannick, Théret, Nathalie
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367906/
https://ncbi.nlm.nih.gov/pubmed/25540073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-1169
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