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Positive and Negative Regulation of Vertebrate Separase by Cdk1-Cyclin B1 May Explain Why Securin Is Dispensable

Sister chromatid cohesion is established during replication by entrapment of both dsDNAs within the cohesin ring complex. It is dissolved in anaphase when separase, a giant cysteine endopeptidase, cleaves the Scc1/Rad21 subunit of cohesin, thereby triggering chromosome segregation. Separase is held...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Hellmuth, Susanne, Pöhlmann, Christopher, Brown, Andreas, Böttger, Franziska, Sprinzl, Mathias, Stemmann, Olaf
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367298/
https://ncbi.nlm.nih.gov/pubmed/25659430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.615310
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