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Single-molecule Analyses of the Dynamics of Heat Shock Protein 104 (Hsp104) and Protein Aggregates

Hsp104 solubilizes protein aggregates in cooperation with Hsp70/40. Although the framework of the disaggregase function has been elucidated, the actual process of aggregate solubilization by Hsp104-Hsp70/40 remains poorly understood. Here we developed several methods to investigate the functions of...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Okuda, Momoko, Niwa, Tatsuya, Taguchi, Hideki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367282/
https://ncbi.nlm.nih.gov/pubmed/25635051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620427
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