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Insight into Molecular Basis of Curing of [PSI(+)] Prion by Overexpression of 104-kDa Heat Shock Protein (Hsp104)

Yeast prions are a powerful model for understanding the dynamics of protein aggregation associated with a number of human neurodegenerative disorders. The AAA+ protein disaggregase Hsp104 can sever the amyloid fibrils produced by yeast prions. This action results in the propagation of “seeds” that a...

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Detalhes bibliográficos
Main Authors: Helsen, Christopher W., Glover, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249108/
https://ncbi.nlm.nih.gov/pubmed/22081611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.302869
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