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Insight into Molecular Basis of Curing of [PSI(+)] Prion by Overexpression of 104-kDa Heat Shock Protein (Hsp104)
Yeast prions are a powerful model for understanding the dynamics of protein aggregation associated with a number of human neurodegenerative disorders. The AAA+ protein disaggregase Hsp104 can sever the amyloid fibrils produced by yeast prions. This action results in the propagation of “seeds” that a...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3249108/ https://ncbi.nlm.nih.gov/pubmed/22081611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.302869 |
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