Third Transmembrane Domain of the Adrenocorticotropic Receptor Is Critical for Ligand Selectivity and Potency

The ACTH receptor, known as the melanocortin-2 receptor (MC2R), plays an important role in regulating and maintaining adrenocortical function. MC2R is a subtype of the melanocortin receptor (MCR) family and has unique characteristics among MCRs. Endogenous ACTH is the only endogenous agonist for MC2...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Yang, Yingkui, Mishra, Vinod, Crasto, Chiquito J., Chen, Min, Dimmitt, Reed, Harmon, Carroll M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367271/
https://ncbi.nlm.nih.gov/pubmed/25605722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.596122
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