Probing the Acceptor Active Site Organization of the Human Recombinant β1,4-Galactosyltransferase 7 and Design of Xyloside-based Inhibitors

Among glycosaminoglycan (GAG) biosynthetic enzymes, the human β1,4-galactosyltransferase 7 (hβ4GalT7) is characterized by its unique capacity to take over xyloside derivatives linked to a hydrophobic aglycone as substrates and/or inhibitors. This glycosyltransferase is thus a prime target for the de...

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Vydáno v:J Biol Chem
Hlavní autoři: Saliba, Mineem, Ramalanjaona, Nick, Gulberti, Sandrine, Bertin-Jung, Isabelle, Thomas, Aline, Dahbi, Samir, Lopin-Bon, Chrystel, Jacquinet, Jean-Claude, Breton, Christelle, Ouzzine, Mohamed, Fournel-Gigleux, Sylvie
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367269/
https://ncbi.nlm.nih.gov/pubmed/25568325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.628123
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