Preserving Mafa Expression in Diabetic Islet β-Cells Improves Glycemic Control in Vivo

The murine Mafa transcription factor is a key regulator of postnatal islet β-cell activity, affecting insulin transcription, insulin secretion, and β-cell mass. Human MAFA expression is also markedly decreased in islet β-cells of type 2 diabetes mellitus (T2DM) patients. Moreover, levels are profoun...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Matsuoka, Taka-aki, Kaneto, Hideaki, Kawashima, Satoshi, Miyatsuka, Takeshi, Tochino, Yoshihiro, Yoshikawa, Atsushi, Imagawa, Akihisa, Miyazaki, Jun-ichi, Gannon, Maureen, Stein, Roland, Shimomura, Iichiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367268/
https://ncbi.nlm.nih.gov/pubmed/25645923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.595579
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