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Structural and molecular determinants of HIV-1 Gag binding to the plasma membrane

Targeting of the Gag polyprotein to the plasma membrane (PM) for assembly is a critical event in the late phase of immunodeficiency virus type-1 (HIV-1) infection. Gag binding to the PM is mediated by interactions between the myristoylated matrix (MA) domain and PM lipids. Despite the extensive bioc...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Vlach, Jiri, Saad, Jamil S.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367181/
https://ncbi.nlm.nih.gov/pubmed/25852680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2015.00232
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