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Trio engagement via plasma membrane phospholipids and the myristoyl moiety governs HIV-1 matrix binding to bilayers

Localization of the HIV type-1 (HIV-1) Gag protein on the plasma membrane (PM) for virus assembly is mediated by specific interactions between the N-terminal myristoylated matrix (MA) domain and phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)]. The PM bilayer is highly asymmetric, and this asym...

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Detalhes bibliográficos
Main Authors: Vlach, Jiri, Saad, Jamil S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587261/
https://ncbi.nlm.nih.gov/pubmed/23401539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216655110
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