In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity.

A method is described that allows for the improvement of antibody affinity. This method, termed complementary-determining region (CDR) walking, does not require structural information on either antibody or antigen. Complementary-determining regions are targeted for random mutagenesis followed by sel...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Barbas, C F, Hu, D, Dunlop, N, Sawyer, L, Cababa, D, Hendry, R M, Nara, P L, Burton, D R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43671/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8170992/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.9.3809
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