Structural and Biophysical Characterization of Human Cytochromes P450 2B6 and 2A6 Bound to Volatile Hydrocarbons: Analysis and Comparison

X-ray crystal structures of complexes of cytochromes CYP2B6 and CYP2A6 with the monoterpene sabinene revealed two distinct binding modes in the active sites. In CYP2B6, sabinene positioned itself with the putative oxidation site located closer to the heme iron. In contrast, sabinene was found in an...

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Publié dans:Mol Pharmacol
Auteurs principaux: Shah, Manish B., Wilderman, P. Ross, Liu, Jingbao, Jang, Hyun-Hee, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366795/
https://ncbi.nlm.nih.gov/pubmed/25585967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.097014
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