2-Acetylcyclopentanone, an Enolate-Forming 1,3-Dicarbonyl Compound, Is Cytoprotective in Warm Ischemia-Reperfusion Injury of Rat Liver

We have previously shown that 2-acetylcyclopentanone (2-ACP), an enolate-forming 1,3-dicarbonyl compound, provides protection in cell culture and animal models of oxidative stress. The pathophysiology of ischemia-reperfusion injury (IRI) involves oxidative stress, and, therefore, we determined the a...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Kosharskyy, Boleslav, Vydyanathan, Amaresh, Zhang, Lihai, Shaparin, Naum, Geohagen, Brian C., Bivin, William, Liu, Qiang, Gavin, Terrence, LoPachin, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366758/
https://ncbi.nlm.nih.gov/pubmed/25659651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.221622
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