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Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor

The bidirectional signaling and hemostatic functions of platelet αIIbβ3 are regulated by kindlin-3 through interactions with the β3 cytoplasmic tail. Little is known about kindlin regulation of the related “vitronectin receptor,” αVβ3. These relationships were investigated in endothelial cells, whic...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Liao, Zhongji, Kato, Hisashi, Pandey, Manjula, Cantor, Joseph M., Ablooglu, Ararat J., Ginsberg, Mark H., Shattil, Sanford J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366628/
https://ncbi.nlm.nih.gov/pubmed/25587038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-603035
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