Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis

STAT3 is considered to play an oncogenic role in several malignancies including lung cancer; consequently, targeting STAT3 is currently proposed as therapeutic intervention. Here we demonstrate that STAT3 plays an unexpected tumour-suppressive role in KRAS mutant lung adenocarcinoma (AC). Indeed, lu...

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Publicado en:Nat Commun
Main Authors: Grabner, Beatrice, Schramek, Daniel, Mueller, Kristina M., Moll, Herwig P., Svinka, Jasmin, Hoffmann, Thomas, Bauer, Eva, Blaas, Leander, Hruschka, Natascha, Zboray, Katalin, Stiedl, Patricia, Nivarthi, Harini, Bogner, Edith, Gruber, Wolfgang, Mohr, Thomas, Zwick, Ralf Harun, Kenner, Lukas, Poli, Valeria, Aberger, Fritz, Stoiber, Dagmar, Egger, Gerda, Esterbauer, Harald, Zuber, Johannes, Moriggl, Richard, Eferl, Robert, Győrffy, Balázs, Penninger, Josef M., Popper, Helmut, Casanova, Emilio
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366489/
https://ncbi.nlm.nih.gov/pubmed/25734337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7285
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