Disruption of the Growth Hormone—Signal Transducer and Activator of Transcription 5—Insulinlike Growth Factor 1 Axis Severely Aggravates Liver Fibrosis in a Mouse Model of Cholestasis

Growth hormone (GH) resistance and low serum levels of insulinlike growth factor 1 (IGF-1) are common features in human liver fibrosis and cirrhosis. Signal transducer and activator of transcription 5 (STAT5) controls several vital functions in the liver, including GH-mediated transcription of IGF-1...

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Библиографические подробности
Главные авторы: Blaas, Leander, Kornfeld, Jan-Wilhelm, Schramek, Daniel, Musteanu, Monica, Zollner, Gernot, Gumhold, Judith, van Zijl, Franziska, Schneller, Doris, Esterbauer, Harald, Egger, Gerda, Mair, Markus, Kenner, Lukas, Mikulits, Wolfgang, Eferl, Robert, Moriggl, Richard, Penninger, Josef, Trauner, Michael, Casanova, Emilio
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976853/
https://ncbi.nlm.nih.gov/pubmed/20162728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23469
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