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Tumor Necrosis Factor: A Mechanistic Link between Angiotensin-II-Induced Cardiac Inflammation and Fibrosis

BACKGROUND: Continuous angiotensin-II (Ang-II) infusion induced the uptake of monocytic fibroblast precursors that initiated the development of cardiac fibrosis; these cells and concurrent fibrosis were absent in mice lacking tumor necrosis factor-alpha receptor 1 (TNFR1). We now investigated their...

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Detalhes bibliográficos
Publicado no:Circ Heart Fail
Main Authors: Duerrschmid, Clemens, Trial, JoAnn, Wang, Yanlin, Entman, Mark L., Haudek, Sandra B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366299/
https://ncbi.nlm.nih.gov/pubmed/25550440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001893
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