Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation

AIMS: Highly proliferative, CD34(+)/CD45(+) fibroblasts derived from monocytic, blood-borne precursor cells play a critical role in the development of fibrosis in a murine ischaemic/reperfusion cardiomyopathy (I/RC) model. The differentiation of human monocytes into fibroblasts in vitro occurs after...

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Autori principali: Haudek, Sandra B., Gupta, Damon, Dewald, Oliver, Schwartz, Robert J., Wei, Lei, Trial, JoAnn, Entman, Mark L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2009
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709463/
https://ncbi.nlm.nih.gov/pubmed/19406912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp135
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