Th1/M1 Conversion to Th2/M2 Responses in Models of Inflammation Lacking Cell Death Stimulates Maturation of Monocyte Precursors to Fibroblasts

We have demonstrated that cardiac fibrosis arises from the differentiation of monocyte-derived fibroblasts. We present here evidence that this process requires sequential Th1 and Th2 induction promoting analogous M1 (classically activated) and M2 (alternatively activated) macrophage polarity. Our mo...

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Detalhes bibliográficos
Main Authors: Trial, JoAnn, Cieslik, Katarzyna A., Haudek, Sandra B., Duerrschmid, Clemens, Entman, Mark L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776235/
https://ncbi.nlm.nih.gov/pubmed/24065967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00287
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