Smoking p66Shc Knocked Out Mice Develop Respiratory Bronchiolitis with Fibrosis but Not Emphysema

The adaptor protein p66Shc regulates intracellular oxidant levels through the modulation of a forkhead-related transcription factor (FOXO3a). The genetic ablation of p66(Shc) (p66(Shc–/–)) renders mice resistant to oxidative stress and p53-dependent apoptosis. We investigated whether p66(Shc) ablati...

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Publicat a:PLoS One
Autors principals: Lunghi, Benedetta, De Cunto, Giovanna, Cavarra, Eleonora, Fineschi, Silvia, Bartalesi, Barbara, Lungarella, Giuseppe, Lucattelli, Monica
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366108/
https://ncbi.nlm.nih.gov/pubmed/25790295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119797
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