Spatially distinct atrophy is linked to β-amyloid and tau in preclinical Alzheimer disease

OBJECTIVES: To determine whether an MRI-based Alzheimer disease (AD) signature biomarker can detect tau-related neurodegeneration in preclinical AD, and to assess whether AD signature cortical thinning is associated with cognitive changes in cognitively normal (CN) older individuals. METHODS: In a l...

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Detalhes bibliográficos
Publicado no:Neurology
Main Authors: Wang, Liang, Benzinger, Tammie L., Hassenstab, Jason, Blazey, Tyler, Owen, Christopher, Liu, Jingxia, Fagan, Anne M., Morris, John C., Ances, Beau M.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366088/
https://ncbi.nlm.nih.gov/pubmed/25716355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000001401
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