Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non–Alzheimer Disease Pathophysiology

IMPORTANCE: Preclinical Alzheimer disease (AD) can be staged using a 2-factor model denoting the presence or absence of β-amyloid (Aβ+/−) and neurodegeneration (ND+/−). The association of these stages with longitudinal biomarker outcomes is unknown. OBJECTIVE: To examine whether longitudinal Aβ accu...

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Bibliographic Details
Published in:JAMA Neurol
Main Authors: Gordon, Brian A., Blazey, Tyler, Su, Yi, Fagan, Anne M., Holtzman, David M., Morris, John C., Benzinger, Tammie L. S.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5237381/
https://ncbi.nlm.nih.gov/pubmed/27548756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2016.2642
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