Cytoplasmic Tyrosine Phosphatase Shp2 Coordinates Hepatic Regulation of Bile Acid and FGF15/19 Signaling to Repress Bile Acid Synthesis

Bile acid (BA) biosynthesis is tightly controlled by intrahepatic negative feedback signaling elicited by BA binding to farnesoid X receptor (FXR), and also by enterohepatic communication involving ileal BA reabsorption and FGF15/19 secretion. However, how these pathways are coordinated is poorly un...

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Publicado no:Cell Metab
Main Authors: Li, Shuangwei, Hsu, Diane D.F., Li, Bing, Luo, Xiaolin, Alderson, Nazilla, Qiao, Liping, Ma, Lina, Zhu, Helen H., He, Zhao, Suino-Powell, Kelly, Ji, Kaihong, Li, Jiefu, Shao, Jianhua, Xu, H. Eric, Li, Tiangang, Feng, Gen-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365973/
https://ncbi.nlm.nih.gov/pubmed/24981838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.05.020
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