Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase

The molecular mechanism underlying adipogenesis and the physiological functions of adipose tissue are not fully understood. We describe here a unique mouse model of severe lipodystrophy. Ablation of Ptpn11/Shp2 in adipocytes, mediated by aP2-Cre, led to premature death, lack of white fat, low blood...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: He, Zhao, Zhu, Helen H., Bauler, Timothy J., Wang, Jing, Ciaraldi, Theodore, Alderson, Nazilla, Li, Shuangwei, Raquil, Marie-Astrid, Ji, Kaihong, Wang, Shufen, Shao, Jianhua, Henry, Robert R., King, Philip D., Feng, Gen-Sheng
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2013
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538237/
https://ncbi.nlm.nih.gov/pubmed/23236157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213000110
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