A Nitric Oxide-Donor Furoxan Moiety Improves the Efficacy of Edaravone against Early Renal Dysfunction and Injury Evoked by Ischemia/Reperfusion

Edaravone (5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, EDV) is a free-radical scavenger reduces organ ischemic injury. Here we investigated whether the protective effects of EDV in renal ischemia/reperfusion (I/R) injury may be enhanced by an EDV derivative bearing a nitric oxide- (NO-) donor fu...

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Pubblicato in:Oxid Med Cell Longev
Autori principali: Chiazza, Fausto, Chegaev, Konstantin, Rogazzo, Mara, Cutrin, Juan C., Benetti, Elisa, Lazzarato, Loretta, Fruttero, Roberta, Collino, Massimo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365375/
https://ncbi.nlm.nih.gov/pubmed/25834700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/804659
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