Knockdown of CDK2AP1 in Primary Human Fibroblasts Induces p53 Dependent Senescence

Cyclin Dependent Kinase-2 Associated Protein-1 (CDK2AP1) is known to be a tumor suppressor that plays a role in cell cycle regulation by sequestering monomeric CDK2, and targeting it for proteolysis. A reduction of CDK2AP1 expression is considered to be a negative prognostic indicator in patients wi...

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Bibliographic Details
Published in:PLoS One
Main Authors: Alsayegh, Khaled N., Gadepalli, Venkat S., Iyer, Shilpa, Rao, Raj R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365013/
https://ncbi.nlm.nih.gov/pubmed/25785833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120782
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