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Knockdown of CDK2AP1 in human embryonic stem cells reduces the threshold of differentiation

Recent studies have suggested a role for the Cyclin Dependent Kinase-2 Associated Protein 1 (CDK2AP1) in stem cell differentiation and self-renewal. In studies with mouse embryonic stem cells (mESCs) derived from generated mice embryos with targeted deletion of the Cdk2ap1 gene, CDK2AP1 was shown to...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Alsayegh, Khaled N., Sheridan, Steven D., Iyer, Shilpa, Rao, Raj Raghavendra
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937771/
https://ncbi.nlm.nih.gov/pubmed/29734353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196817
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