Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA

Cytosine residues in mammalian DNA occur in five forms, cytosine (C), 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). The ten-eleven translocation (Tet) dioxygenases convert 5mC to 5hmC, 5fC and 5caC in three consecutive, Fe(II)- and α-ke...

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Publicado en:Nature
Main Authors: Hashimoto, Hideharu, Pais, June E., Zhang, Xing, Saleh, Lana, Fu, Zheng-Qing, Dai, Nan, Corrêa, Ivan R., Zheng, Yu, Cheng, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364404/
https://ncbi.nlm.nih.gov/pubmed/24390346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12905
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