Initial viral load determines the magnitude of the human CD8 T cell response to yellow fever vaccination

CD8 T cells are a potent tool for eliminating intracellular pathogens and tumor cells. Thus, eliciting robust CD8 T-cell immunity is the basis for many vaccines under development. However, the relationship between antigen load and the magnitude of the CD8 T-cell response is not well-described in a h...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Akondy, Rama S., Johnson, Philip L. F., Nakaya, Helder I., Edupuganti, Srilatha, Mulligan, Mark J., Lawson, Benton, Miller, Joseph D., Pulendran, Bali, Antia, Rustom, Ahmed, Rafi
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364194/
https://ncbi.nlm.nih.gov/pubmed/25713354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500475112
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