Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration

Dendritic cells (DCs) are the primary leukocytes responsible for priming T cells. To find and activate naïve T cells, DCs must migrate to lymph nodes, yet the cellular programs responsible for this key step remain unclear. DC migration to lymph nodes and the subsequent T-cell response are disrupted...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Krishnaswamy, Jayendra Kumar, Singh, Arpita, Gowthaman, Uthaman, Wu, Renee, Gorrepati, Pavane, Sales Nascimento, Manuela, Gallman, Antonia, Liu, Dong, Rhebergen, Anne Marie, Calabro, Samuele, Xu, Lan, Ranney, Patricia, Srivastava, Anuj, Ranson, Matthew, Gorham, James D., McCaw, Zachary, Kleeberger, Steven R., Heinz, Leonhard X., Müller, André C., Bennett, Keiryn L., Superti-Furga, Giulio, Henao-Mejia, Jorge, Sutterwala, Fayyaz S., Williams, Adam, Flavell, Richard A., Eisenbarth, Stephanie C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364188/
https://ncbi.nlm.nih.gov/pubmed/25713392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501554112
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